Product Name :
STAT3 Recombinant Rabbit Monoclonal Antibody [SY34-01]
Predicted band size :
88 kDa
Observed band size :
88 kDa
Synonyms:
1110034C02Rik antibody Acute Phase Response Factor antibody Acute-phase response factor antibody ADMIO antibody APRF antibody AW109958 antibody DNA binding protein APRF antibody FLJ20882 antibody HIES antibody MGC16063 antibody 展开
Function :
Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by Prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within C-terminal human STAT3.3-Hydroxy-4-methylbenzonitrile Chemical name
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IF-Cell, IF-Tissue, IHC-P
Coupling :
unconjugated
Clone number:
SY34-01
RRID:
AB_3069715
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.(S)-(-)-tert-Butylsulfinamide structure Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.PMID:33516645
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 88 kDa
Positive control :
HeLa cell lysate, HaCaT cell lysate, Mouse brain tissue lysate, Rat brain tissue lysate, Rat kidney tissue lysate, Hela, A549, HepG2, mouse pancreas tissue, human stomach carcinoma tissue, human breast carcinoma tissue, mouse brain tissue.