Product Name :
UNC5B Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
6330415E02Rik antibody A630020F16 antibody D10Bwg0792e antibody Netrin receptor UNC5B antibody Netrin receptor UNC5B Precursor antibody p53 regulated receptor for death and life antibody p53 regulated receptor for death and life protein 1 antibody p53-regulated receptor for death and life protein 1 antibody p53RDL1 antibody Protein unc-5 homolog 2 antibody 展开
Function :
FunctionReceptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
KLH conjugated synthetic peptide derived from human UNC5B 188-260/945
Species reactivity:
Human, Mouse, Rat, Dog, Pig, Horse, Rabbit
Verify application:
WB, ELISA, IHC-P, IF, ICC
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
Storage buffer solution:
0.1,3-Benzoxazol-5-amine Price 01M TBS(pH7.3-Methoxybenzensulfonyl chloride Order 4) with 1% BSA, 0.PMID:33439054 03% Proclin300 and 50% Glycerol.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
101 KDa
Positive control :
Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.